Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening
نویسندگان
چکیده
منابع مشابه
Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening.
RAD51 is a key protein of homologous recombination that plays a critical role in the repair of DNA double-strand breaks (DSB) and interstrand cross-links (ICL). To better understand the cellular function(s) of human RAD51, we propose to develop specific RAD51 inhibitors. RAD51 inhibitors may also help to increase the potency of anticancer drugs that act by inducing DSBs or ICLs, e.g., cisplatin...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2011
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb100428c